Endocrine Abstracts

Aim: Our previousstudies have shown evidence for insulin-releasing actions of some amphibian skin peptides; including esculentin-2CHa. However, there is a need to further improve the potency of some of this peptides and to characterize their other beneficial effects. This study investigates the effect of a Leu31→Lys substitution on the insulin-releasing and immunomodulatory effects of esculentin-2CHa.Methods: BRIN-BD11 cells were incubat...

Aim: Insulin-releasing effects and potential anti-diabetic actions of peptides isolated from the skin secretion of the African clawed frog, Xenopus amieti has been reported. However, peptides such as magainin-AM1 has not been previously studied for its ability to stimulate insulin secretion or promote glucose uptake. This study investigated insulin releasing effects as well as possible underlying mechanisms.Methods: Acute and chronic actions of ...

Aim: Our previous studies indicated the potential antidiabetic actions of the amphibian host-defence peptide, tigerinin-1. Tigerinin-1R was conjugated with gastric inhibitory polypeptide (GIP) as part of strategies for further development of its therapeutic effects. This study characterises the insulin-releasing and cytotoxic properties of the resulting hybrid peptide.Method: Pure G-TGN was commercially synthesized G-TGN. Insulin releasing effects were a...

Aim: The use of commonly consumed vegetables, such as Pterocarpus mildbraedii, in the treatment of metabolic conditions is consistent with the food-as-medicine strategy. To characterise its pharmacological actions, this study assessed insulin-releasing and glucose lowering effects of effects of P. mildbraedii in models of type 2 diabetes.Methods: Clonal pancreatic cells, BRIN-BD11, were treated P. mildbraedii extracts...